Cardoso F E, Jankovic J
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.
Mov Disord. 1993 Apr;8(2):175-8. doi: 10.1002/mds.870080210.
We describe four patients, two with Tourette's syndrome, one with the combination of idiopathic dystonia and essential-like tremor, and one with tardive dystonia, who noted marked exacerbation of their movement disorders after exposure to cocaine. These patients provide support for the hypothesis that dopaminergic preponderance plays an important role in the pathogenesis of certain hyperkinetic movement disorders. Cocaine should be regarded as an important cause or precipitant of hyperkinetic movement disorders.
我们描述了四名患者，其中两名患有妥瑞氏综合征，一名患有特发性肌张力障碍与类原发性震颤的组合病症，另一名患有迟发性肌张力障碍，他们在接触可卡因后，其运动障碍均显著加剧。这些患者为如下假说提供了支持，即多巴胺能优势在某些运动亢进性运动障碍的发病机制中起重要作用。可卡因应被视为运动亢进性运动障碍的一个重要病因或诱发因素。
