鞘内注射咪达唑仑和芬太尼对 Aδ 和 C 躯体交感反射的镇痛作用之间的协同效应。

Synergism between the antinociceptive effects of intrathecal midazolam and fentanyl on both A delta and C somatosympathetic reflexes.

作者信息

Wang C, Chakrabarti M K, Whitwam J G

机构信息

Department of Anaesthetics, Hammersmith Hospital, Royal Postgraduate Medical School, London, U.K.

出版信息

Neuropharmacology. 1993 Mar;32(3):303-5. doi: 10.1016/0028-3908(93)90116-k.

DOI:10.1016/0028-3908(93)90116-k

PMID:8474627

Abstract

The interaction between the antinociceptive effects of fentanyl and midazolam, administered intrathecally (i.t.), was examined in dogs. Midazolam 1 mg (i.t) depressed the A delta and C fibre mediated somatosympathetic reflexes to 68.3 and 85.2% of control values and then reduced the subsequent doses of fentanyl (i.t.) required to abolish these reflexes by 50%. After midazolam (1 mg, i.t.) the ED values for fentanyl were markedly less than the theoretical predicted additive values. This indicates synergism between the effects of fentanyl and midazolam.

摘要

在犬类中研究了鞘内注射（i.t.）芬太尼和咪达唑仑的镇痛效果之间的相互作用。鞘内注射1毫克咪达唑仑可将Aδ和C纤维介导的躯体交感反射分别抑制至对照值的68.3%和85.2%，随后使消除这些反射所需的芬太尼后续鞘内注射剂量减少50%。在注射咪达唑仑（1毫克，鞘内注射）后，芬太尼的半数有效剂量（ED值）明显低于理论预测的相加值。这表明芬太尼和咪达唑仑的作用之间存在协同效应。