Nagai K, Stoynev A G, Nagai N, Nakagawa H
Division of Protein Research, Osaka University, Japan.
Neurosci Lett. 1993 Jan 12;149(2):217-20. doi: 10.1016/0304-3940(93)90775-g.
We compared the plasma renin activity (PRA) before and after 24-h water-deprivation in blind hereditary microphthalmic rats and Donryu rats. In the congenitally blind rats with a morphologically abnormal suprachiasmatic nucleus (SCN), hypovolemia induced significantly less elevation of the PRA and significantly more increase in the hematocrit value than in normal rats. The changes after water-deprivation in the blind rats were quite similar to those reported in rats with SCN lesions. However, the free-running circadian rhythms persisted in these blind rats, whereas those in rats with SCN lesions were completely eliminated. Thus, it is likely that SCN cells are involved in regulation of the PRA, and that if this is the case these cells are different from those containing the circadian pacemaker.
我们比较了遗传性盲性小眼大鼠和唐律大鼠在禁水24小时前后的血浆肾素活性（PRA）。在先天性盲性大鼠中，其视交叉上核（SCN）形态异常，与正常大鼠相比，血容量不足引起的PRA升高明显较少，而血细胞比容值的增加明显更多。盲性大鼠禁水后的变化与报道的SCN损伤大鼠的变化非常相似。然而，这些盲性大鼠的自由运行昼夜节律仍然存在，而SCN损伤大鼠的昼夜节律则完全消失。因此，SCN细胞可能参与PRA的调节，如果是这样，这些细胞与含有昼夜起搏器的细胞不同。
