Sugahara K, Nagai K, Isojima Y, Nagai N, Sugita S, Nakagawa H
Department of Animal Science, Faculty of Agriculture, Utsunomiya University, Tochigi, Japan.
Exp Anim. 1997 Apr;46(2):141-5. doi: 10.1538/expanim.46.141.
In normal rats, 24-hr water-deprivation was found to cause a significant increase in the plasma concentration of arginine vasopressin (AVP), and marked induction of Fos in the AVP-positive magnocellular neurons in the paraventricular nucleus (PVN) and the supraoptic nucleus (SON) of the hypothalamus. On the other hand, 24-hr water-deprivation also caused a significant increase in the plasma AVP concentration in hereditary microphthalmic rats, but much less than in normal rats. Consistent with this, the extent of induction of Fos in the nuclei of the PVN and SON of these rats was lesser than in normal rats. These results suggest that hereditary microphthalmic rats have a defect or decrease in the response to water-deprivation of vasopressinergic magnocellular neurons in the PVN and SON.
在正常大鼠中，发现24小时禁水会导致精氨酸加压素（AVP）的血浆浓度显著升高，并在下丘脑室旁核（PVN）和视上核（SON）中AVP阳性大细胞神经元中显著诱导Fos表达。另一方面，24小时禁水也导致遗传性小眼大鼠的血浆AVP浓度显著升高，但远低于正常大鼠。与此一致的是，这些大鼠PVN和SON细胞核中Fos的诱导程度低于正常大鼠。这些结果表明，遗传性小眼大鼠在对PVN和SON中加压素能大细胞神经元缺水的反应方面存在缺陷或降低。
