McGeown J G, Crockard A D
School of Biomedical Science (Physiology), Medical Biology Centre, Queen's University of Belfast, Northern Ireland.
Pflugers Arch. 1993 Feb;422(5):533-5. doi: 10.1007/BF00375083.
Lymphocytes migrate and recirculate continuously between blood and lymph. The current study compared the migratory properties of lymphocyte subsets by labelling lymphocyte surface antigens and analysing simultaneous samples of mesenteric lymph, systemic arterial blood and mesenteric venous blood from conscious sheep. The lymphocyte output in lymph averaged 5.33 +/- 0.89 x 10(6) min-1 (lymph flow rate of 92 +/- 13 microliters min-1, lymphocyte count 61.9 +/- 10.7 x 10(9) l-1, n = 10) and the proportion of cells which carried the CD4 antigen (CD4+) was considerably higher in lymph (46 +/- 3%) than in arterial blood (23 +/- 2%; p < 0.01, n = 9). This increase was paralleled by a small but statistically significant decrease in the percentage of CD4+ cells in mesenteric venous blood (20 +/- 2%), as compared with systemic arterial blood (26 +/- 2%; p < 0.05, n = 6), which is consistent with the hypothesis that CD4+ cells migrate out of the blood vessels, and recirculate through the lymphatics, more readily than other lymphocyte subsets.
淋巴细胞在血液和淋巴之间持续迁移和再循环。当前研究通过标记淋巴细胞表面抗原并分析清醒绵羊的肠系膜淋巴、体循环动脉血和肠系膜静脉血的同步样本，比较了淋巴细胞亚群的迁移特性。淋巴中淋巴细胞的输出平均为5.33±0.89×10⁶个/分钟（淋巴流速为92±13微升/分钟，淋巴细胞计数为61.9±10.7×10⁹个/升，n = 10），携带CD4抗原（CD4⁺）的细胞比例在淋巴中（46±3%）显著高于动脉血中（23±2%；p < 0.01，n = 9）。与体循环动脉血（26±2%；p < 0.05，n = 6）相比，肠系膜静脉血中CD4⁺细胞百分比略有下降但具有统计学意义（20±2%），这与CD4⁺细胞比其他淋巴细胞亚群更容易从血管中迁移出来并通过淋巴管再循环的假设一致。
