爱沙尼亚人对异喹胍和苯妥英羟化作用的多态性

Polymorphism of debrisoquine and mephenytoin hydroxylation among Estonians.

作者信息

Kiivet R A, Svensson J O, Bertilsson L, Sjöqvist F

机构信息

Department of Pharmacology, Tartu University, Estonia.

出版信息

Pharmacol Toxicol. 1993 Feb;72(2):113-5. doi: 10.1111/j.1600-0773.1993.tb00300.x.

DOI:10.1111/j.1600-0773.1993.tb00300.x

PMID:8474964

Abstract

Debrisoquine and S-mephenytoin hydroxylation polymorphisms were studied in 156 unrelated native Estonians. The hydroxylation phenotypes were assessed by coadministration of mephenytoin with debrisoquine or dextromethorphan. The frequency of the poor metaboliser phenotype of debrisoquine/dextromethorphan was 4.5% (95% confidence interval 1.2-7.8%), and that of mephenytoin was 3.9% (95% confidence interval 0.9-6.9%) among Estonians, which is very similar to what has been reported in other Caucasian populations.

摘要

对156名无亲缘关系的爱沙尼亚本地人进行了异喹胍和S-美芬妥因羟基化多态性研究。通过同时给予美芬妥因和异喹胍或右美沙芬来评估羟基化表型。在爱沙尼亚人中，异喹胍/右美沙芬慢代谢者表型的频率为4.5%（95%置信区间1.2 - 7.8%），美芬妥因的频率为3.9%（95%置信区间0.9 - 6.9%），这与其他高加索人群的报道非常相似。