Debrisoquine hydroxylation in a Polish population.

作者信息

Kunicki P K, Sitkiewicz D, Pawlik A, Bielicka-Sulzyc V, Borowiecka E, Gawrońska-Szklarz B, Sterna R, Matsumoto H, Radziwoń-Zaleska M

机构信息

Department of Clinical Biochemistry, National Institute of Cardiology, Warszawa, Poland.

出版信息

Eur J Clin Pharmacol. 1995;47(6):503-5. doi: 10.1007/BF00193702.

The genetic polymorphism of drug oxidation mediated by cytochrome P450IID6 (CYP2D6) was determined in 154 Polish volunteers using debrisoquine as the test substance. The results showed a bimodal distribution of the debrisoquine metabolic ratio (MR). Nine persons (5.8%) with MR > 12.6 were classified as poor metabolisers (gene frequency 0.242), which is in substantial agreement with the data reported for other Caucasian populations.