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1,5 - 二芳基 - 3 - 烷基氨基 - 4 - 羧甲基 - 2,5 - 二氢吡咯 - 2 - 酮和1,5 - 二芳基 - 4 - 羧甲基四氢吡咯 - 2,3 - 二酮的合成与生物活性

[Synthesis and biological activity of 1,5-diaryl-3-alkylamino-4-carboxymethyl-2,5-dihydropyrrol-2-ones and 1,5-diaryl-4-carboxymethyltetrahydropyrrol-2,3-diones].

作者信息

Gein V L, Popov A V, Kolla W E, Popova N A

机构信息

Pharmazeutisches Institut, Perm, Russland.

出版信息

Pharmazie. 1993 Feb;48(2):107-9.

PMID:8475156
Abstract

By interaction of alpha-ketoglutaric acid with Schiff bases 1,5-diaryl-3-arylamino-4-carboxymethyl-2,5-dihydropyrrol-2-ones 1 were obtained. Hydrolysis of the latter, carried out with hydrochloride acid gave 1,5-diaryl-3-hydroxy-4-carboxymethyl-2,5-dihydropyrrol-2-ones 2. On treatment of 2 with aryl-amines the starting compounds 1 were yielded. All compounds were tested for their antiphlogistic activity.

摘要

通过α-酮戊二酸与席夫碱的相互作用，得到了1,5-二芳基-3-芳氨基-4-羧甲基-2,5-二氢吡咯-2-酮1。用盐酸对后者进行水解，得到1,5-二芳基-3-羟基-4-羧甲基-2,5-二氢吡咯-2-酮2。用芳胺处理2，得到起始化合物1。对所有化合物进行了抗炎活性测试。

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