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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Hindmarch I, Sherwood N, Kerr J S

Human Psychopharmacology Research Unit, Robens Institute, University of Surrey, Milford Hospital, Godalming, UK.

Prog Neuropsychopharmacol Biol Psychiatry. 1993 May;17(3):407-13. doi: 10.1016/0278-5846(93)90074-3.

The effects of a number of hypnotics were compared to a range of results collected for triazolam on objective measures of CNS sedation (critical flicker fusion) and short-term memory function (memory scanning). 2. Assessments taken after the drugs had been administered but prior to the onset of sleep showed that in comparison to placebo most of the compounds were effective sedatives and this correlated highly (r = 0.734, p < 0.04) with amnestic effects found at the same time, suggesting that general CNS sedation is a major component of anterograde amnesia. 3. Residual effects assessed the morning after the hypnotics had been used showed a similar relationship (r = 0.896, p < 0.005). 4. The distribution of results indicates that 0.25 mg triazolam has an acute amnestic profile which is similar to other hypnotics, but possesses a distinct lack of residual effects.

将多种催眠药的效果与收集到的一系列三唑仑在中枢神经系统镇静客观指标（临界闪烁融合）和短期记忆功能（记忆扫描）方面的结果进行了比较。2. 在给药后但睡眠开始前进行的评估表明，与安慰剂相比，大多数化合物都是有效的镇静剂，并且这与同时发现的遗忘效应高度相关（r = 0.734，p < 0.04），表明中枢神经系统的一般性镇静是顺行性遗忘的主要组成部分。3. 在使用催眠药后的次日早晨评估的残留效应显示出类似的关系（r = 0.896，p < 0.005）。4. 结果分布表明，0.25毫克三唑仑具有与其他催眠药相似的急性遗忘特征，但明显缺乏残留效应。

Hindmarch I, Sherwood N, Kerr J S

Human Psychopharmacology Research Unit, Robens Institute, University of Surrey, Milford Hospital, Godalming, UK.

Prog Neuropsychopharmacol Biol Psychiatry. 1993 May;17(3):407-13. doi: 10.1016/0278-5846(93)90074-3.

The effects of a number of hypnotics were compared to a range of results collected for triazolam on objective measures of CNS sedation (critical flicker fusion) and short-term memory function (memory scanning). 2. Assessments taken after the drugs had been administered but prior to the onset of sleep showed that in comparison to placebo most of the compounds were effective sedatives and this correlated highly (r = 0.734, p < 0.04) with amnestic effects found at the same time, suggesting that general CNS sedation is a major component of anterograde amnesia. 3. Residual effects assessed the morning after the hypnotics had been used showed a similar relationship (r = 0.896, p < 0.005). 4. The distribution of results indicates that 0.25 mg triazolam has an acute amnestic profile which is similar to other hypnotics, but possesses a distinct lack of residual effects.

将多种催眠药的效果与收集到的一系列三唑仑在中枢神经系统镇静客观指标（临界闪烁融合）和短期记忆功能（记忆扫描）方面的结果进行了比较。2. 在给药后但睡眠开始前进行的评估表明，与安慰剂相比，大多数化合物都是有效的镇静剂，并且这与同时发现的遗忘效应高度相关（r = 0.734，p < 0.04），表明中枢神经系统的一般性镇静是顺行性遗忘的主要组成部分。3. 在使用催眠药后的次日早晨评估的残留效应显示出类似的关系（r = 0.896，p < 0.005）。4. 结果分布表明，0.25毫克三唑仑具有与其他催眠药相似的急性遗忘特征，但明显缺乏残留效应。