Berlin I, Warot D, Hergueta T, Molinier P, Bagot C, Puech A J
Department of Clinical Pharmacology, Hôpital Pitié-Salpêtrière, Paris, France.
J Clin Psychopharmacol. 1993 Apr;13(2):100-6.
Zolpidem is a rapid-onset, short-duration imidazopyridine hypnotic drug and is specific agonist of the omega-1 (BZD1) receptors. Its hypnotic characteristics resemble those of triazolam. The aims of this study were to assess the effects of zolpidem on memory (the main objective), psychomotor performances, and postural sway (secondary objectives) in 18 healthy subjects and to compare them with those of triazolam and placebo. Short- and long-term memory (paired words associate and pictures test), psychomotor performances (critical flicker fusion frequency, choice reaction time, digit symbol substitution test), and postural sway were evaluated before and 1.5, 4, 6, and 8 h after the administration of a single dose of zolpidem (10 mg), triazolam (0.25 mg), and placebo. For each assessment, the maximal effect for both hypnotic drugs occurred 1.5 hour after intake. Both drugs decreased psychomotor performance, impaired memory, and increased postural sway. The effects of both hypnotic agents were short lasting, and no alterations were found 6 and 8 hours, respectively, after drug intake. No clinically relevant differences were found between zolpidem and triazolam for memory, psychomotor performance, postural sway, or adverse effects. It may be concluded that zolpidem, like triazolam, impairs short- and long-term memory, psychomotor performances, and postural sway and that these effects are of short duration.
唑吡坦是一种起效迅速、作用时间短暂的咪唑吡啶类催眠药物，是ω-1（苯二氮䓬1型，BZD1）受体的特异性激动剂。其催眠特性类似于三唑仑。本研究的目的是评估唑吡坦对18名健康受试者记忆（主要目标）、精神运动表现和姿势摇摆（次要目标）的影响，并将其与三唑仑和安慰剂的影响进行比较。在单次服用唑吡坦（10毫克）、三唑仑（0.25毫克）和安慰剂之前以及服药后1.5、4、6和8小时，对短期和长期记忆（配对词联想和图片测试）、精神运动表现（临界闪烁融合频率、选择反应时间、数字符号替换测试）和姿势摇摆进行评估。对于每项评估，两种催眠药物的最大效应均在服药后1.5小时出现。两种药物均降低了精神运动表现、损害了记忆并增加了姿势摇摆。两种催眠药物的作用持续时间较短，分别在服药后6小时和8小时未发现有变化。在记忆、精神运动表现、姿势摇摆或不良反应方面，唑吡坦和三唑仑之间未发现临床相关差异。可以得出结论，唑吡坦与三唑仑一样，会损害短期和长期记忆、精神运动表现以及姿势摇摆，且这些影响持续时间较短。
