Yaksh T L
Department of Anesthesiology, University of California, San Diego, La Jolla 92093-0818.
Semin Oncol. 1993 Apr;20(2 Suppl 1):6-18.
Advances in the management of pain are predicated on the development of our understanding of the underlying systems. This report briefly reviews the peripheral and central substrates that define several mechanisms whereby peripheral mechanical, thermal, and chemical stimuli are encoded. Of particular interest is the growing appreciation of the changes in spinal function that occur with peripheral nerve injury and with repetitive small afferent input. These changes may serve to provide insight into a variety of pain states that are refractory to conventional management approaches.
疼痛管理的进展基于我们对潜在系统理解的发展。本报告简要回顾了定义外周机械、热和化学刺激编码的几种机制的外周和中枢基础。特别值得关注的是，人们越来越认识到外周神经损伤和重复性小传入输入时脊髓功能发生的变化。这些变化可能有助于深入了解各种对传统管理方法难治的疼痛状态。
