针对1,1'-亚乙基双[L-色氨酸]（EBT）制备多克隆抗体，EBT是一种可能导致嗜酸性粒细胞增多性肌痛综合征（EMS）的污染物。

Production of polyclonal antibodies against 1,1'-ethyliden bis[L-tryptophan] (EBT), a potential contaminant causing eosinophilia-myalgia syndrome (EMS).

作者信息

Kurihara N, Yanagisawa H, Jin Z, Wada O

机构信息

Department of Hygiene and Preventive Medicine, Faculty of Medicine, University of Tokyo, Japan.

出版信息

Toxicol Lett. 1993 Mar;66(3):231-6. doi: 10.1016/0378-4274(93)90003-g.

DOI:10.1016/0378-4274(93)90003-g

Abstract

Eosinophilia-myalgia syndrome (EMS) is thought to be caused by the intake of contaminated L-tryptophan products. 1,1'-Ethyliden bis[L-tryptophan] (EBT) is one of the contaminants in the L-tryptophan products and is thought to be a possible cause of EMS. In the present study we report that anti-EBT antibodies are generated by immunizing rabbits with the low molecular weight substance, EBT (molecular weight 434). These antibodies may be available tools for elucidating the mechanisms responsible for the outbreak and/or development of EMS.

摘要

嗜酸性粒细胞增多性肌痛综合征（EMS）被认为是由摄入受污染的L-色氨酸产品所致。1,1'-亚乙基双[L-色氨酸]（EBT）是L-色氨酸产品中的污染物之一，被认为是EMS的一个可能病因。在本研究中，我们报告用低分子量物质EBT（分子量434）免疫兔子可产生抗EBT抗体。这些抗体可能是阐明EMS爆发和/或发展机制的有用工具。

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