Dreno B, Celerier P, Litoux P
Department of Dermatology, Hôtel Dieu, Nantes, France.
Acta Haematol. 1993;89 Suppl 1:28-32. doi: 10.1159/000204582.
In cutaneous T-cell lymphomas (CTCL; mycosis fungoides and Sézary syndrome), the standard therapies tend to be effective but not curative. Single drug therapy with either interferon-alpha or retinoids shows a response rate of about 45%. In this article, we report the results obtained in the treatment of CTCL with a combined therapy. To date, four clinical studies have been carried out using a combination of low doses of interferon-alpha and retinoids for treatment in the early stages of CTCL. The mechanism of action of this combination therapy is unknown.
