干扰素在皮肤T细胞淋巴瘤治疗中的应用。

The Use of Interferons in the Treatment of Cutaneous T-Cell Lymphoma.

作者信息

Spaccarelli Natalie, Rook Alain H

机构信息

Department of Dermatology, Hospital of the University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA.

出版信息

Dermatol Clin. 2015 Oct;33(4):731-45. doi: 10.1016/j.det.2015.05.008. Epub 2015 Aug 20.

DOI:10.1016/j.det.2015.05.008

PMID:26433845

Abstract

Interferons are polypeptides that naturally occur in the human body as a part of the innate immune response. By harnessing these immunomodulatory functions, synthetic interferons have shown efficacy in combating various diseases including cutaneous T-cell lymphoma. This article closely examines the qualities of interferon alfa and interferon gamma and the evidence behind their use in the 2 most common types of cutaneous T-cell lymphomas, namely, mycosis fungoides and Sézary syndrome.

摘要

干扰素是作为先天性免疫反应的一部分自然存在于人体中的多肽。通过利用这些免疫调节功能，合成干扰素已显示出对包括皮肤T细胞淋巴瘤在内的各种疾病具有疗效。本文仔细研究了α干扰素和γ干扰素的特性以及它们用于两种最常见的皮肤T细胞淋巴瘤（即蕈样肉芽肿和塞扎里综合征）的证据。