Spaccarelli Natalie, Rook Alain H
Department of Dermatology, Hospital of the University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA.
Department of Dermatology, Hospital of the University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA.
Dermatol Clin. 2015 Oct;33(4):731-45. doi: 10.1016/j.det.2015.05.008. Epub 2015 Aug 20.
Interferons are polypeptides that naturally occur in the human body as a part of the innate immune response. By harnessing these immunomodulatory functions, synthetic interferons have shown efficacy in combating various diseases including cutaneous T-cell lymphoma. This article closely examines the qualities of interferon alfa and interferon gamma and the evidence behind their use in the 2 most common types of cutaneous T-cell lymphomas, namely, mycosis fungoides and Sézary syndrome.
干扰素是作为先天性免疫反应的一部分自然存在于人体中的多肽。通过利用这些免疫调节功能，合成干扰素已显示出对包括皮肤T细胞淋巴瘤在内的各种疾病具有疗效。本文仔细研究了α干扰素和γ干扰素的特性以及它们用于两种最常见的皮肤T细胞淋巴瘤（即蕈样肉芽肿和塞扎里综合征）的证据。
