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[使用铟111奥曲肽对类癌转移患者进行的初次及随访研究——善宁的合理应用]

[Primary and follow-up studies of patients with carcinoid metastases using indium 111 octreotide--rational use of Sandostatin].

作者信息

Lipp R W, Hammer H F, Passath A, Dobnig H, Ramschak-Schwarzer S, Stiegler C, Leb G, Krejs G J

机构信息

Abteilungen für Nuklearmedizin und Endokrinologie, Medizinischen Universitätsklinik, Karl-Franzens-Universität, Graz.

出版信息

Acta Med Austriaca. 1993;20(1-2):42-4.

PMID:8475679
Abstract

Carcinoids may express Somatostatin receptors. Therefore, a Somatostatin-analogue, In-111 Octreotide (OctreoScan), was used for their demonstration. A total of 6 patients who presented with radiologically verified carcinoid-metastases was examined. In order to control tumor progress, 4 of these patients were reexamined within a period of 3 to 11 months. All of the radiological findings were confirmed scintigraphically, except some small retroperitoneally located lymph nodes. The follow-up examinations of 2 patients revealed additional metastases by scintigraphy only. There were no false positive results. The results of OctreoScan scintigraphy may be used for predicting the success of receptor-specific therapies and therefore, permit the rational and efficient application of Sandostatin.

摘要

类癌可能表达生长抑素受体。因此,一种生长抑素类似物,铟 - 111奥曲肽(OctreoScan),被用于其显像。总共检查了6例经放射学证实有类癌转移的患者。为了控制肿瘤进展,其中4例患者在3至11个月内进行了复查。除了一些位于腹膜后的小淋巴结外,所有放射学检查结果均通过闪烁显像得到证实。2例患者的随访检查仅通过闪烁显像发现了额外的转移灶。没有假阳性结果。OctreoScan闪烁显像的结果可用于预测受体特异性治疗的成功率,因此,有助于合理有效地应用善得定。

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