Tiran B, Karpf E, Tiran A, Lax S, Langsteger W, Eber O, Lorenz O
Institut für Medizinische Biochemie, Universität Graz.
Acta Med Austriaca. 1993;20(1-2):6-8.
The iodine concentration was determined in 89 thyroid tissue samples of post-mortem examination material of thyroid healthy persons in dependency to the age. Before the 22nd week little iodine is stored in the fetal thyroid gland (median and range: 24 micrograms/g wet weight [0 to 27 micrograms/g]). From the 23rd week on the concentration is significantly higher (p = 0.004). There is a further increase of iodine concentration in the first 6 months of life, with a median concentration of 171 micrograms/g (75 to 808 micrograms/g). With a median of 599 micrograms/g (464 to 699 micrograms/g) the iodine concentration in the second year of life is comparable with that of adults (640 micrograms/g [218 to 2772 micrograms/g]). From the 60th year of life the median concentration is 462 micrograms/g (155 to 2100 micrograms/g), but this decrease is not statistically significant. Additionally the iodine concentration was determined in 7 topographically defined regions of 28 thyroid glands. The median iodine concentration did not differ in the 7 regions, but the iodine content in one and the same thyroid gland differed from region to region. Therefore in the healthy thyroid gland no regions exist, which have generally stored less iodine than others. However, no conclusion can be drawn from the iodine concentration of one biopsy to the whole iodine concentration of the organ.
在89份甲状腺健康者尸检材料的甲状腺组织样本中,根据年龄测定了碘浓度。在第22周之前,胎儿甲状腺中储存的碘很少(中位数和范围:24微克/克湿重[0至27微克/克])。从第23周开始,浓度显著升高(p = 0.004)。在生命的前6个月中,碘浓度进一步升高,中位数浓度为171微克/克(75至808微克/克)。生命第二年的碘浓度中位数为599微克/克(464至699微克/克),与成年人相当(640微克/克[218至2772微克/克])。从60岁开始,中位数浓度为462微克/克(155至2100微克/克),但这种下降在统计学上并不显著。此外,在28个甲状腺的7个按地形定义的区域中测定了碘浓度。7个区域的碘浓度中位数没有差异,但同一个甲状腺内不同区域的碘含量不同。因此,在健康的甲状腺中,不存在普遍储存碘比其他区域少的区域。然而,不能从一次活检的碘浓度推断出整个器官的碘浓度。