Ostermeyer-Shoaib B, Patten B M
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.
Acta Neurol Scand. 1993 Mar;87(3):192-4. doi: 10.1111/j.1600-0404.1993.tb04099.x.
In order to get to clues about T-cell independent versus T-cell dependent immune mechanism in ALS, we measured IgG subclasses in 25 ALS-patients: 16 patients had deficiency of T-cell dependent expressed IgG1 or IgG3 or both with essentially normal levels of T-cell independent expressed IgG2 and IgG4. Ten of these patients had no prior treatment and five of these 10 had normal total IgG. Six patients had some immunosuppressive treatment before measurements of subclasses were done and all of them had deficiency of total IgG. Eight of 14 patients who underwent a d-xylose breath test, had evidence of small bowel overgrowth, which was confirmed by cultures of duodenal aspirate. IgG1 and IgG3 are T-cell dependent antibodies against protein antigens with close linkage on chromosome 14. The findings suggest a defect in the IgG subclass expression in ALS.
为了探寻肌萎缩侧索硬化症（ALS）中T细胞非依赖性与T细胞依赖性免疫机制的线索，我们检测了25例ALS患者的IgG亚类：16例患者存在T细胞依赖性表达的IgG1或IgG3或两者均缺乏，而T细胞非依赖性表达的IgG2和IgG4水平基本正常。其中10例患者未接受过先前治疗，这10例中的5例总IgG正常。6例患者在检测亚类之前接受过一些免疫抑制治疗，他们的总IgG均缺乏。14例接受d-木糖呼气试验的患者中有8例有小肠细菌过度生长的证据，十二指肠抽吸物培养证实了这一点。IgG1和IgG3是针对蛋白抗原的T细胞依赖性抗体，在14号染色体上有紧密连锁。这些发现提示ALS中存在IgG亚类表达缺陷。
