Rasmussen K, Arlien-Søborg P, Sabroe S
Institute of Epidemiology and Social Medicine, University of Aarhus, Denmark.
Acta Neurol Scand. 1993 Mar;87(3):200-4. doi: 10.1111/j.1600-0404.1993.tb04101.x.
Among industrial solvents in present use trichloroethylene belongs to those which have been the concern of most neurological and occupational investigations since the beginning of this century. Reports on a broad spectrum of neurotoxicity are however mostly based on case-studies and accidental circumstances. The object of this study was to examine clinical neurological manifestations after long-term exposure to degreasing solvents, mainly trichloroethylene. The population was 99 metal degreasers, the design a historical cohort study. The most marked finding was a highly significant dose-response relation between solvent exposure and motor dyscoordination--a finding that was retained after multivariate control of relevant confounders. Vibration thresholds increased by solvent exposure at bivariate level, but the multivariate analysis showed that age was explaining most of the increase. No significant cranial nerve dysfunction was found.
在目前使用的工业溶剂中，自本世纪初以来，三氯乙烯就属于那些备受大多数神经学和职业调查关注的溶剂。然而，关于广泛神经毒性的报告大多基于个案研究和意外情况。本研究的目的是检查长期接触脱脂溶剂（主要是三氯乙烯）后的临床神经学表现。研究对象为99名金属脱脂工人，采用历史性队列研究设计。最显著的发现是溶剂暴露与运动失调之间存在高度显著的剂量反应关系——这一发现经对相关混杂因素进行多变量控制后依然成立。在双变量水平上，溶剂暴露会使振动阈值升高，但多变量分析表明，年龄可以解释大部分升高情况。未发现明显的颅神经功能障碍。
