Rasmussen K, Brogren C H, Sabroe S
Institute of Epidemiology and Social Medicine, University of Aarhus, Denmark.
Int Arch Occup Environ Health. 1993;64(6):445-8. doi: 10.1007/BF00517951.
The role of solvents as hepato- and nephrotoxic agents under present-day exposure levels is still unclear. The purpose of this study involving 99 metal degreasers was to examine dose-response relationships between long-term exposure of mainly trichloroethylene and a battery of liver function tests and one nephrotubular enzyme test. Serum gamma-glutamyltransferase and urinary N-acetyl-beta-glucosaminidase were elevated by increasing solvent exposure at bivariate level. The significance of this relationship, however, was not able to withstand a multiple regression analysis, with age and alcohol abuse as confounding variables. The conclusion is that of a nonsignificant association between solvent exposure and tests screening for early liver and kidney dysfunction.
