Ger E, Dall D, Miles T, Forder A
S Afr Med J. 1977 Feb 26;51(9):276-9.
Antibiotics of various kinds were added to the powdered polymer of methylmethacrylate in a concentration of 1 g antibiotic/40 g cement, prior to the addition of the liquid monomer. Specimens were subjected to mechanical testing by loading them in direct compression on a 20-ton Instron Universal Testing Machine, and load deflection curves were recorded. It was found that the addition of antibiotics does have an effect on the mechanical strength of the cement--the loss was small, less than 10% for both the compressive strength and the elastic modulus, provided the antibiotic was in powder form. Liquid antibiotics resulted in a greater loss of the compressive strength of the mixtures, but specimens tended to be less porous. In vitro studies of the antibiotic properties of the mixtures demonstrated potent antibacterial activity in all the antibiotics tested, except chloramphenicol. Possible clinical applications are discussed. Further in vivo studies are needed before widespread clinical use can be advocated.
在添加液态单体之前，将各种抗生素以1克抗生素/40克骨水泥的浓度添加到聚甲基丙烯酸甲酯粉末状聚合物中。通过在一台20吨的英斯特朗万能试验机上对标本进行直接压缩加载来进行力学测试，并记录载荷-挠度曲线。结果发现，添加抗生素确实会对骨水泥的力学强度产生影响——如果抗生素为粉末形式，抗压强度和弹性模量的损失都很小，不到10%。液态抗生素会导致混合物的抗压强度有更大损失，但标本的孔隙率往往较小。对混合物抗生素特性的体外研究表明，除氯霉素外，所有测试的抗生素都具有强大的抗菌活性。文中讨论了可能的临床应用。在提倡广泛临床应用之前，还需要进一步的体内研究。
