Hankins G D, Snyder R R, Clark S L, Schwartz L, Patterson W R, Butzin C A
Department of Obstetrics and Gynecology, Wilford Hall USAF Medical Center SGHO, Lackland AFB, TX 78236-5300.
Am J Obstet Gynecol. 1993 Apr;168(4):1113-29; discussion 1129-30. doi: 10.1016/0002-9378(93)90355-m.
Our purpose was to determine the acute-phase central hemodynamic and respiratory effects of raw, filtered, filtered and boiled, and meconium-containing amniotic fluid.
Pregnant goats (Capra hircus) in the last one third of pregnancy were given freshly collected autologous amniotic fluid in a volume of 2.5 ml/kg of body weight. Observations were then made at 10, 30, 60, 120, and 180 minutes after amniotic fluid embolism. Pulmonary artery catheters and femoral artery lung water catheters were placed for specimen and data collection.
Marked pressor responses were observed in both the pulmonary and systemic circulations with all amniotic fluid infusions. The pressor response was similar with raw, filtered, and filtered and boiled amniotic fluid. The pressor response seen with amniotic fluid containing meconium was significantly greater than that seen with the other forms. No significant effects were observed on cardiac or respiratory function except in the meconium group, where transient left ventricular dysfunction was accompanied by an acute increase in extravascular lung water and dysoxia.
The Capra hircus model is appropriate for the further study of amniotic fluid embolism. The acute pressor effects are transient and involve both the systemic and pulmonary circulations. Left ventricular dysfunction and dysoxia were observed only with embolism of amniotic fluid containing meconium.
我们的目的是确定未经处理、经过滤、经过滤并煮沸以及含有胎粪的羊水的急性期中心血流动力学和呼吸效应。
给妊娠最后三分之一阶段的怀孕山羊（Capra hircus）输注2.5毫升/千克体重的新鲜采集的自体羊水。在羊水栓塞后10、30、60、120和180分钟进行观察。放置肺动脉导管和股动脉肺水导管用于样本采集和数据收集。
所有羊水输注后，在肺循环和体循环中均观察到明显的升压反应。未经处理、经过滤以及经过滤并煮沸的羊水引起的升压反应相似。含有胎粪的羊水引起的升压反应明显大于其他形式的羊水。除了胎粪组，未观察到对心脏或呼吸功能有显著影响，在胎粪组中，短暂的左心室功能障碍伴有血管外肺水急性增加和低氧血症。
Capra hircus模型适用于进一步研究羊水栓塞。急性升压效应是短暂的，涉及体循环和肺循环。仅在含有胎粪的羊水栓塞时观察到左心室功能障碍和低氧血症。
