Kirschbaum T
Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY 10467.
Am J Obstet Gynecol. 1993 Apr;168(4):1239-46. doi: 10.1016/0002-9378(93)90375-s.
Clinical evidence for a relationship between chorioamnionitis and the onset of preterm labor, supported by well developed biochemical models of that interaction, motivated a review of prospective, randomized trials of antibiotic use in its prevention.
A literature search was made of antibiotic trials applied to women at risk for preterm labor and with a clinical diagnosis of preterm labor after premature preterm rupture of membranes. A review of two retrospective case-control studies conducted on pregnant women with positive cultures for Chlamydia trachomatis is also included.
Results of antibiotic use in women with preterm premature rupture of membranes supports significant prolongation of the interval from rupture of membranes to delivery and improvement and neonatal outcome in treated patients.
绒毛膜羊膜炎与早产发作之间关系的临床证据，得到了该相互作用完善的生化模型的支持，这促使人们对预防早产时使用抗生素的前瞻性随机试验进行综述。
对应用于有早产风险且在胎膜早破后临床诊断为早产的女性的抗生素试验进行了文献检索。还纳入了两项对沙眼衣原体培养阳性的孕妇进行的回顾性病例对照研究的综述。
对胎膜早破早产女性使用抗生素的结果支持显著延长从胎膜破裂到分娩的间隔时间，并改善治疗患者的新生儿结局。
