Lea M A, Xiao Q, Sadhukhan A, Sharma S, Newmark H L
Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark 07103.
Anticancer Res. 1993 Jan-Feb;13(1):145-9.
Butyramide and monobutyrin were chosen for study as neutral compounds that might exhibit some of the growth inhibitory and differentiating effects of butyrate. Inhibitory effects on DNA synthesis in hepatoma cells and on cellular proliferation in mouse erythroleukemia cells were observed. Induction of differentiation by butyramide and monobutyrin was seen in mouse erythroleukemia cells as monitored by increased synthesis of hemoglobin and H1 zero histone. Butyramide and monobutyrin were less effective inducers of hemoglobin synthesis than butyrate but their neutral character may offer an advantage in the induction of tumor cell differentiation.
选择丁酰胺和甘油一丁酸酯作为中性化合物进行研究，它们可能展现出丁酸盐的一些生长抑制和分化作用。观察到它们对肝癌细胞DNA合成以及小鼠红白血病细胞的细胞增殖具有抑制作用。在小鼠红白血病细胞中，通过血红蛋白和H1零组蛋白合成增加监测到丁酰胺和甘油一丁酸酯可诱导细胞分化。丁酰胺和甘油一丁酸酯诱导血红蛋白合成的效果不如丁酸盐，但它们的中性特性可能在诱导肿瘤细胞分化方面具有优势。
