Carbone D P, Minna J D
Simmons Cancer Center, Dallas, Texas.
Annu Rev Med. 1993;44:451-64. doi: 10.1146/annurev.me.44.020193.002315.
Multiple genetic lesions are thought to transform a normal cell into a malignant one, and both dominant and recessive genetic effects have been identified in this process. Antioncogenes (or tumor suppressor genes) act in a recessive manner, in which both maternal and paternal alleles need to be inactivated to abrogate normal function. The identification of these lesions is giving us insight into the regulatory pathways in the cell and may translate into future improvements in prevention, diagnosis, prognosis, and therapy of human cancer.
多种基因损伤被认为会将正常细胞转变为恶性细胞，并且在这一过程中已识别出显性和隐性遗传效应。抗癌基因（或肿瘤抑制基因）以隐性方式起作用，即母本和父本等位基因都需要失活才能消除正常功能。这些损伤的识别让我们深入了解细胞中的调控途径，并且可能转化为未来人类癌症在预防、诊断、预后和治疗方面的改善。
