Bessette L, Boulet L P, Tremblay G, Cormier Y
Unité de recherche, Hôpital Laval Sainte-Foy, Québec, Canada.
Arch Environ Health. 1993 Mar-Apr;48(2):73-7. doi: 10.1080/00039896.1993.9938397.
Bronchial responsiveness to methacholine was measured in 60 swine confinement building workers selected from 461 subjects who participated in a recent epidemiologic survey on the respiratory impact of exposure to this environment. Subjects were divided into the following four groups: group 1, asymptomatic with normal spirometry (n = 16); group 2, asymptomatic with forced expiratory volume in one second/forced vital capacity (FEV1.0/FVC) < 95% predicted (n = 17); group 3, presence of chronic bronchitis with normal respiratory function (n = 13); and group 4, both symptomatic and FEV1.0/FVC < 95% predicted (n = 14). Each subject answered a questionnaire and had a physical examination, PA and lateral chest films, lung volumes and DLCO measurements, and a methacholine bronchoprovocation test. Ages were similar in each group. Physical examination, chest x-rays, and DLCO were normal in all subjects. Values of total lung capacity (TLC) for subjects in group 4 were higher than those of subjects in group 3, and respiratory volume (RV) values of group 4 subjects were higher than those found for all other groups. The provocation dose of methacholine (PC20) was lower for group 4, and the number of subjects with PC20 < 16 mg/ml was greater in this group than in the other groups. We conclude that only swine confinement building workers with both symptoms of chronic bronchitis and abnormal spirometry have an increased bronchial responsiveness to methacholine; however, it is uncertain whether the bronchial responsiveness demonstrated is directly related to the subjects' employment.
从461名参与近期关于接触这种环境对呼吸道影响的流行病学调查的受试者中选取了60名猪场建筑工人，测量了他们对乙酰甲胆碱的支气管反应性。受试者被分为以下四组：第1组，无症状且肺功能正常（n = 16）；第2组，无症状但一秒用力呼气量/用力肺活量（FEV1.0/FVC）<预测值的95%（n = 17）；第3组，有慢性支气管炎但呼吸功能正常（n = 13）；第4组，有症状且FEV1.0/FVC<预测值的95%（n = 14）。每位受试者都回答了一份问卷，并进行了体格检查、胸部正位和侧位X线片、肺容量和一氧化碳弥散量（DLCO）测量以及乙酰甲胆碱支气管激发试验。每组的年龄相似。所有受试者的体格检查、胸部X线片和DLCO均正常。第4组受试者的肺总量（TLC）值高于第3组受试者，第4组受试者的残气量（RV）值高于其他所有组。第4组乙酰甲胆碱的激发剂量（PC20）较低，且该组中PC20<16mg/ml的受试者数量多于其他组。我们得出结论，只有患有慢性支气管炎症状且肺功能异常的猪场建筑工人对乙酰甲胆碱的支气管反应性增加；然而，所表现出的支气管反应性是否与受试者的工作直接相关尚不确定。
