Colosio C, Maroni M, Barcellini W, Meroni P, Alcini D, Colombi A, Cavallo D, Foa V
Institute of Occupational Health, University of Milan, Italy.
Arch Environ Health. 1993 Mar-Apr;48(2):81-8. doi: 10.1080/00039896.1993.9938399.
Pentachlorophenol (PCP) is a pesticide used worldwide in industrial and domestic applications. Data available on the effects of technical-grade PCP on the immune system are insufficient and equivocal; some data indicate inhibitory effects, whereas others suggest stimulating effects. This study was performed to evaluate toxicological and immune findings in 32 subjects who had prolonged exposure to PCP in a wood factory and in 37 controls. PCP concentrations were determined in plasma and urine of all subjects. Lymphocyte subsets of CD3-, CD4-, and CD8-positive cells were evaluated, and the proliferative response of peripheral blood mononuclear cells (PBM) to mitogens was assessed. The results suggested the absence of major laboratory and clinical signs of PCP-dependent immune deficiency. A weak effect of long-term exposure to PCP on the functional immune response could not be ruled out because of the finding of a decreased response to 5% PHA in the high-exposure group. A weak effect against hepatocyte membrane was evidenced by the finding of raised serum concentration of glycocholic, taurodeoxycholic, and glycochenodeoxycholic acids in subjects directly exposed to PCP for more than 10 y.
五氯苯酚（PCP）是一种在全球范围内用于工业和家庭用途的杀虫剂。关于工业级PCP对免疫系统影响的数据不足且存在矛盾；一些数据表明有抑制作用，而另一些则表明有刺激作用。本研究旨在评估32名在木材厂长期接触PCP的受试者和37名对照组受试者的毒理学和免疫学结果。测定了所有受试者血浆和尿液中的PCP浓度。评估了CD3、CD4和CD8阳性细胞的淋巴细胞亚群，并评估了外周血单核细胞（PBM）对有丝分裂原的增殖反应。结果表明不存在PCP依赖性免疫缺陷的主要实验室和临床体征。由于在高暴露组中发现对5%PHA的反应降低，不能排除长期接触PCP对功能性免疫反应有微弱影响。在直接接触PCP超过10年的受试者中，血清甘氨胆酸、牛磺脱氧胆酸和甘氨鹅脱氧胆酸浓度升高，证明对肝细胞膜有微弱影响。
