Daniel V, Huber W, Bauer K, Opelz G
Department of Transplantation Immunology, University of Heidelberg Rehabilitation Hospital, Germany.
Arch Environ Health. 1995 Jul-Aug;50(4):287-92. doi: 10.1080/00039896.1995.9935956.
Immune parameters were examined in 188 patients who were exposed for more than 6 mo to pentachlorophenol-containing pesticides. Blood levels of pentachlorophenol, lymphocyte subpopulations, in-vitro responses to mitogenic and allogeneic stimulation, plasma neopterin levels, and plasma cytokine and cytokine receptor levels were determined. Impaired in-vitro lymphocyte stimulation responses were impaired in 65% of the patients. The likelihood of impaired lymphocyte stimulation increased significantly with levels of pentachlorophenol that exceeded 10 microliters/l (p < .05). Patients who had high blood levels of pentachlorophenol and abnormal lymphocyte stimulation also had increased proportions of blood monocytes in blood (p < .05), as well as increased IL-8 serum levels (p < .02). Eleven patients who had abnormal mitogen stimulation experienced decreased CD4/CD8 ratios of < 1.0; 5 of these patients had decreased CD4+ lymphocyte counts of < 500/microliters, and 3 patients had increased plasma neopterin of > 15 nmol/l. These results indicate that increased levels of pentachlorophenol in blood can lead to severe T lymphocyte dysfunction.
对188名接触含五氯苯酚农药超过6个月的患者的免疫参数进行了检查。测定了血液中五氯苯酚水平、淋巴细胞亚群、对有丝分裂原和同种异体刺激的体外反应、血浆新蝶呤水平以及血浆细胞因子和细胞因子受体水平。65%的患者体外淋巴细胞刺激反应受损。当五氯苯酚水平超过10微升/升时，淋巴细胞刺激受损的可能性显著增加（p < 0.05）。血液中五氯苯酚水平高且淋巴细胞刺激异常的患者，血液中单核细胞比例也增加（p < 0.05），血清白细胞介素-8水平也升高（p < 0.02）。11名有丝分裂原刺激异常的患者CD4/CD8比值降低至< 比值为< 1.0；其中5名患者CD4 + 淋巴细胞计数降低至< 500/微升，3名患者血浆新蝶呤升高至> 15纳摩尔/升。这些结果表明，血液中五氯苯酚水平升高可导致严重的T淋巴细胞功能障碍。
