Ely D L, Falvo J, Dunphy G, Caplea A, Salisbury R, Turner M
Department of Biology, University of Akron, OH 44325-3908.
J Hypertens. 1994 Jul;12(7):769-74.
To investigate the relationship between testosterone and blood pressure during the rapid development phase of blood pressure rise in four strains of rats: Wistar-Kyoto (WKY) rats; spontaneously hypertensive rats (SHR); SHR/y, a substrain with an SHR Y chromosome and WKY rat autosomes and X chromosomes; and SHR/a, a substrain with SHR autosomes and X chromosomes and the WKY rat Y chromosome.
Blood pressure was measured every 2 weeks by the tail-cuff method, and was verified in selected rats at 23 weeks by aortic telemetry. Serum testosterone was measured, by radioimmunoassay, every 2 weeks from 5 to 23 weeks of age.
During the rapid phase of blood pressure rise, between 5 and 9 weeks of age, there was a significantly larger rise in serum testosterone in SHR and SHR/y than in WKY rats and SHR/a groups. The hypertensive Y chromosome in the SHR and SHR/y accelerated peak testosterone approximately 4 weeks earlier, and blood pressure was increased in these two groups compared with the SHR/a and WKY rat groups, respectively. A gene on the SHR Y chromosome (Tty) affecting the timing of testosterone in development is proposed. At approximately 15 weeks of age testosterone levels decreased sharply towards prepubertal levels in WKY rats and at 23 weeks in SHR/y, whereas testosterone levels were maintained in SHR and SHR/a, which suggests an autosomal component.
The SHR Y chromosome may accelerate the start of puberty and a cascade of molecular and neuroendocrine events that raise blood pressure.
研究在血压快速上升阶段，睾酮与四种品系大鼠血压之间的关系，这四种品系大鼠分别为：Wistar - Kyoto（WKY）大鼠；自发性高血压大鼠（SHR）；SHR/y，一种具有SHR Y染色体以及WKY大鼠常染色体和X染色体的亚系；以及SHR/a，一种具有SHR常染色体和X染色体以及WKY大鼠Y染色体的亚系。
每2周通过尾套法测量血压，并在23周时通过主动脉遥测法对选定的大鼠进行验证。从5至23周龄，每2周通过放射免疫测定法测量血清睾酮。
在5至9周龄血压快速上升阶段，SHR和SHR/y血清睾酮的上升幅度显著大于WKY大鼠和SHR/a组。SHR和SHR/y中的高血压Y染色体使睾酮峰值提前约4周出现，并且与SHR/a和WKY大鼠组相比，这两组的血压均升高。提出了SHR Y染色体上一个影响发育中睾酮分泌时间的基因（Tty）。在约15周龄时，WKY大鼠的睾酮水平急剧下降至青春期前水平，而SHR/y在23周时出现这种情况，而SHR和SHR/a的睾酮水平保持稳定，这表明存在常染色体成分。
SHR Y染色体可能加速青春期开始以及引发血压升高的一系列分子和神经内分泌事件。
