Kihl B O, Boden G, Landor J H
Surgery. 1977 Apr;81(4):386-91.
The effect of intraduodenal infusion of olive oil, bile, or a mixture of olive oil and bile on pentagastrin-stimulated gastric secretion, bile flow, and serum immunoreactive secretin levels was studied in dogs. Bile alone had no effect on gastric secretion, but the mixture of bile and olive oil induced prompt, statistically significant gastric secretory inhibition. Bile had the early choleretic effect that would be expected to result from the absorption of bile salts, whereas the bile--olive oil mixture brought about a delayed amd much greater increase in bile flow rates. None of the agents given intraduodenally produced a significant change in the serum secretin level. Intravenous pentagastrin infusion caused a significant increase in rate of bile flow.
在犬身上研究了十二指肠内输注橄榄油、胆汁或橄榄油与胆汁的混合物对五肽胃泌素刺激的胃液分泌、胆汁流量和血清免疫反应性促胰液素水平的影响。单独的胆汁对胃液分泌没有影响，但胆汁与橄榄油的混合物可迅速引起具有统计学意义的胃液分泌抑制。胆汁具有早期利胆作用，这是胆盐吸收预期产生的结果，而胆汁与橄榄油的混合物使胆汁流速出现延迟且大幅增加。十二指肠内给予的任何一种药物均未使血清促胰液素水平发生显著变化。静脉输注五肽胃泌素导致胆汁流速显著增加。
