Kisfalvi I
Acta Hepatogastroenterol (Stuttg). 1978 Dec;25(6):487-91.
In 10 duodenal ulcer patients gastric acid secretion was stimulated by intravenous infusion of 1.5 microgram pentagastrin per kilogram hour. When acid secretion had reached a plateau, glucagon in a dose of 30 microgram per kilogram hour, secretin in a dose of 1 IU per kilogram hour or caerulein in a dose of 0.1 microgram per kilogram hour were infused into a separate vein for one hour during the intravenous infusion of pentagastrin. Using these doses, each drug produced about 30 per cent inhibition given separately. The highest degree of inhibition was obtained by the combination of glucagon and secretin. The inhibition reached the sum of the inhibitions after glucagon and secretin administered separately. Caerulein added to glucagon or secretin could slightly increase the inhibitory effect of these drugs given separately. Caerulein, however, failed to increase inhibition when glucagon and secretin were infused simultaneously.
对10例十二指肠溃疡患者，以每千克体重每小时静脉输注1.5微克五肽胃泌素的方式刺激胃酸分泌。当胃酸分泌达到平台期时，在静脉输注五肽胃泌素的过程中，将每千克体重每小时30微克的胰高血糖素、每千克体重每小时1国际单位的促胰液素或每千克体重每小时0.1微克的蛙皮素经另一静脉输注1小时。使用这些剂量时，每种药物单独使用时均可产生约30%的抑制作用。胰高血糖素和促胰液素联合使用时抑制程度最高。这种抑制作用达到了胰高血糖素和促胰液素单独给药后抑制作用之和。将蛙皮素添加到胰高血糖素或促胰液素中，可略微增强这些药物单独使用时的抑制作用。然而，当同时输注胰高血糖素和促胰液素时，蛙皮素未能增强抑制作用。
