Chodoff P, Imbembo A L, Knowles C L, Margand P M
Surgery. 1977 Apr;81(4):399-403.
Twelve morbidly obese patients had jejunoileal bypass surgery and serial detailed pulmonary function studies done over a one year period. Before operation they showed evidence of a decreased ventilation: perfusion ratio producing a "shuntlike effect" (Pao2 = 73, Paco2 = 37, pH = 7.44) while breathing room air (FIo2 = 0.209). They also had measurements consistent with pure restrictive lung disease. There was a highly significant improvement in the arterial oxygenation over the entire one year period and a significant loss of chest wall mass over the first 6 month period. The improved oxygenation most likely was due to a return of lung volumes toward normal and an improvement in the efficiency of the respiratory muscles.
12名病态肥胖患者接受了空肠回肠分流术，并在一年时间内进行了一系列详细的肺功能研究。术前，他们表现出通气与灌注比例下降，产生“分流样效应”（呼吸室内空气时，动脉血氧分压=73，动脉血二氧化碳分压=37，pH=7.44）（吸入氧分数=0.209）。他们的测量结果也符合单纯限制性肺病。在整个一年期间，动脉氧合有显著改善，在前6个月期间胸壁质量显著减轻。氧合改善最可能是由于肺容积恢复正常以及呼吸肌效率提高。
