Cabrera R, Agar A, Dahl M V
Department of Dermatology, University of Chile School of Medicine, Santiago.
Semin Dermatol. 1993 Mar;12(1):15-21.
Individuals with scabies react to bites by generating a cell-mediated immune response at the bite site. This elicits a very itchy papule that is often excoriated. Sometimes ulcerated papules, vasculitis, and nodules develop as a result of other immunologic reactions in skin. Immunologic reactions mediated by antibodies of the immunoglobulin G (IgG), IgM, and especially, IgE classes may also be involved. None of these reactions have been shown to eliminate all mites from the skin surface, but locally these reactions may prevent the epidemic multiplication of scabies' organisms on the skin surface, as observed in some patients with crusted scabies.
疥疮患者会在叮咬部位产生细胞介导的免疫反应，对叮咬做出反应。这会引发非常瘙痒的丘疹，且该丘疹常被抓破。有时，由于皮肤中的其他免疫反应，会出现溃疡丘疹、血管炎和结节。免疫球蛋白G（IgG）、IgM，尤其是IgE类抗体介导的免疫反应也可能参与其中。这些反应均未被证明能从皮肤表面清除所有螨虫，但在某些结痂性疥疮患者中观察到，局部这些反应可能会阻止疥疮病原体在皮肤表面大量繁殖。
