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经宫颈子宫内膜切除术与腹式子宫切除术治疗月经过多的经济学评估。

An economic evaluation of transcervical endometrial resection versus abdominal hysterectomy for the treatment of menorrhagia.

作者信息

Sculpher M J, Bryan S, Dwyer N, Hutton J, Stirrat G M

机构信息

Brunel University, Uxbridge, Middlesex.

出版信息

Br J Obstet Gynaecol. 1993 Mar;100(3):244-52. doi: 10.1111/j.1471-0528.1993.tb15238.x.

Abstract

OBJECTIVE

To evaluate the relative health service cost of endometrial resection versus abdominal hysterectomy for the treatment of menorrhagia and the value women attach to their health state before and after surgery.

DESIGN

A prospective economic evaluation running alongside a randomised controlled trial.

SETTING

The gynaecology department of a teaching hospital.

SUBJECTS

200 women requiring surgical treatment of menorrhagia between January 1990 and May 1991; after withdrawals, 97 women underwent hysterectomy and 99 underwent endometrial resection.

MAIN OUTCOME MEASURES

The total health service cost of managing women in the two arms of the trial until 4 months after their operation. The change in women's valuation of their health state a fortnight after and a minimum of 4 months after surgery relative to that 1 month prior to their operation.

RESULTS

Total health service costs are significantly higher amongst abdominal hysterectomy patients (mean 1059.73 pounds) than amongst endometrial resection patients with a mean difference of 499.68 pounds (95% CI 432 pounds-567 pounds). This significant difference exists under alternative assumptions about the difference in lengths of stay in hospital between the two treatment groups and the hotel cost per in-patient day. On a scale of 0 to 100, relative to a month before surgery, there is a statistically significant difference in favour of endometrial resection between the two groups in the increase in value women attach to their health state at a fortnight after surgery (mean difference 11.2; 95% CI 0.6-21.7), but not at a minimum of 4 months after surgery (mean difference 7; 95% CI -17.4 to 3.4).

CONCLUSIONS

On the basis of health service resource cost up to 4 months after surgery, endometrial resection has a cost advantage over abdominal hysterectomy. However, given the fact that a subgroup of women requires retreatment due to resection failure and that this study considers a relatively short period of follow up, the long term costs and benefits of endometrial resection need to be evaluated before widespread diffusion is justified.

摘要

目的

评估子宫内膜切除术与经腹子宫切除术治疗月经过多的相对卫生服务成本,以及女性对手术前后健康状况的重视程度。

设计

一项与随机对照试验同时进行的前瞻性经济评估。

地点

一家教学医院的妇科。

研究对象

1990年1月至1991年5月间200名需要手术治疗月经过多的女性;剔除部分病例后,97名女性接受了子宫切除术,99名女性接受了子宫内膜切除术。

主要观察指标

试验两组女性术后4个月内的卫生服务总成本。女性在术后两周及至少术后4个月相对于术前1个月对自身健康状况评估的变化。

结果

经腹子宫切除术患者的卫生服务总成本(平均1059.73英镑)显著高于子宫内膜切除术患者,平均差值为499.68英镑(95%可信区间432英镑 - 567英镑)。在关于两个治疗组住院时间差异和每位住院患者每日酒店费用的不同假设下,这一显著差异均存在。在0至100的量表上,相对于手术前1个月,两组在术后两周女性对自身健康状况重视程度的增加值方面,子宫内膜切除术具有统计学显著优势(平均差值11.2;95%可信区间0.6 - 21.7),但在术后至少4个月时则无此优势(平均差值7;95%可信区间 - 17.4至3.4)。

结论

基于术后4个月内的卫生服务资源成本,子宫内膜切除术相对于经腹子宫切除术具有成本优势。然而,鉴于部分女性因切除失败需要再次治疗,且本研究随访期相对较短,在广泛推广子宫内膜切除术之前,需要评估其长期成本和效益。

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