Friedland R P, Lerner A J, Hedera P, Brass E P
Department of Neurology, University Hospitals of Cleveland, Case Western Reserve University, Ohio 44106.
Clin Neuropharmacol. 1993 Apr;16(2):173-6. doi: 10.1097/00002826-199304000-00010.
A 74-year-old man developed paranoid ideation, memory impairment, and defective gustatory and olfactory function while on bismuth subgallate therapy for use as a colostomy deodorant. Twenty-four-hour urine bismuth was elevated at 889 micrograms/day, and whole blood bismuth concentration was 67 micrograms/L. The patient improved after discontinuation of bismuth subgallate; there was resolution of paranoid behavior and gustatory and olfactory functions improved. Follow-up whole blood bismuth concentration was 21 micrograms/L 4 weeks after cessation. Altered gustatory and olfactory function have not been previously reported with bismuth intoxication.
一名74岁男性在使用碱式没食子酸铋作为结肠造口除臭剂治疗期间出现偏执观念、记忆障碍以及味觉和嗅觉功能缺陷。24小时尿铋升高至889微克/天，全血铋浓度为67微克/升。停用碱式没食子酸铋后患者病情好转；偏执行为消失，味觉和嗅觉功能改善。停药4周后随访全血铋浓度为21微克/升。碱式没食子酸中毒此前未见有味觉和嗅觉功能改变的报道。
