微小毛霉和紫色链霉菌对（-）-埃博纳明的微生物羟基化作用。
Microbial hydroxylation of (-)-eburnamonine by Mucor circinelloides and Streptomyces violens.
作者信息
Adachi T, Saito M, Sasaki J, Karasawa Y, Araki H, Hanada K, Omura S
机构信息
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1993 Mar;41(3):611-3. doi: 10.1248/cpb.41.611.
PMID:8477514
Abstract
(6R)-6-Hydroxy-, (6S)-6-hydroxy- and (18S)-18-hydroxyeburnamonines were obtained by microbial conversion of (-)-eburnamonine using Mucor circinelloides and Streptomyces violens. Their structures were determined by analyses of the mass, 1H- and 13C-NMR spectra. (-)-Eburnamonine and the three hydroxylated compounds showed cerebral protecting effects against potassium cyanide intoxication in mice.
摘要
使用卷枝毛霉和紫色链霉菌对（-）-埃博纳明进行微生物转化，得到了（6R）-6-羟基-、（6S）-6-羟基-和（18S）-18-羟基埃博纳明。通过对质谱、1H-和13C-NMR光谱的分析确定了它们的结构。（-）-埃博纳明和这三种羟基化化合物对小鼠氰化钾中毒表现出脑保护作用。
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