Golaz J, Bouras C
University Department of Psychiatry, Geneva, Switzerland.
Clin Neuropathol. 1993 Mar-Apr;12(2):73-8.
The purpose of this study is to report a case of a very large arachnoid cyst in a patient having spent a very active life and who had never presented any neurological or psychiatric symptomatology beside a dementia in the last years of her life. The gross examination of the brain revealed the presence of a voluminous frontal bilateral cyst, located in the midline and displacing laterally the frontal lobes, so they displayed a foliated aspect. Microscopically, the examination of the cyst walls confirmed its arachnoid origin and the cerebral cortex contained lesions typical for senile dementia. This case exemplifies the histological nature and the pathogeny of arachnoid cysts, in particular of congenital origin. This also shows that the very early occurrence of such a malformation does not prevent the development of functional neuronal pathways, owing to the important plasticity of the central nervous system.
本研究的目的是报告一例患有非常大的蛛网膜囊肿的患者病例。该患者一生都非常活跃，除了在生命的最后几年出现痴呆症外，从未出现过任何神经或精神症状。大脑的大体检查发现有一个巨大的双侧额叶囊肿，位于中线，将额叶向外侧推移，因此额叶呈现出叶状外观。显微镜下，囊肿壁的检查证实了其蛛网膜起源，大脑皮层包含典型的老年痴呆症病变。该病例例证了蛛网膜囊肿，尤其是先天性蛛网膜囊肿的组织学性质和发病机制。这也表明，由于中枢神经系统具有重要的可塑性，这种畸形的早期出现并不妨碍功能性神经元通路的发育。
