Shand J H, Crilly P J, West D W
Hannah Research Institute, Ayr, UK.
FEBS Lett. 1993 Apr 26;321(2-3):132-4. doi: 10.1016/0014-5793(93)80093-a.
The soluble fraction from a number of macrophage cell lines has been shown to contain a protein(s) that inhibits neutral cholesteryl ester hydrolase. The inhibition is dependent on the concentration of soluble protein used, and the efficiency of the inhibitor can be influenced by the inclusion of oleate and an inhibitor of ACAT. It is suggested that the presence of this material indicates that the macrophage contains a means of negatively controlling the activity of the hydrolytic phase of the cholesterol/cholesteryl ester cycle.
已证明多种巨噬细胞系的可溶性组分含有一种抑制中性胆固醇酯水解酶的蛋白质。这种抑制作用取决于所用可溶性蛋白质的浓度，并且油酸和ACAT抑制剂的存在会影响抑制剂的效率。有人认为，这种物质的存在表明巨噬细胞含有一种对胆固醇/胆固醇酯循环水解阶段的活性进行负调控的方式。
