甲状腺激素可恢复垂体切除大鼠心房牵张诱导的心房利钠肽分泌。

Thyroid hormone restores atrial stretch-induced secretion of atrial natriuretic peptide in hypophysectomized rats.

作者信息

Zamir N, Slover M, Ohman K P

机构信息

Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Israel.

出版信息

Horm Metab Res. 1993 Mar;25(3):152-5. doi: 10.1055/s-2007-1002066.

DOI:10.1055/s-2007-1002066

PMID:8477952

Abstract

Acute blood volume expansion caused a rapid and profound release of atrial natriuretic peptides (ANP) from cardiac atria. The stimulated release of ANP was markedly blunted (more than 50%) in hypophysectomized rats (8 days after surgery). Daily subcutaneous injections of thyroxine (30 micrograms/kg) to hypophysectomized rats for 7 days, completely restored acute volume expansion induced release of ANP. Our data suggest that thyroid hormone is required for ANP secretion in response to acute volume expansion.

摘要

急性血容量扩张导致心房利钠肽（ANP）从心脏心房快速且大量释放。在垂体切除的大鼠（手术后8天）中，ANP的刺激释放明显减弱（超过50%）。对垂体切除的大鼠每天皮下注射甲状腺素（30微克/千克），持续7天，可完全恢复急性容量扩张诱导的ANP释放。我们的数据表明，甲状腺激素是急性容量扩张时ANP分泌所必需的。