补充类固醇激素脱氢表雄酮可逆转与年龄相关的对肺炎免疫疫苗免疫反应的衰退。
Reversal of age-associated decline in immune response to Pnu-imune vaccine by supplementation with the steroid hormone dehydroepiandrosterone.
作者信息
Garg M, Bondada S
机构信息
Department of Microbiology and Immunology, Sanders-Brown Center on Aging, University of Kentucky, Lexington 40536-0230.
出版信息
Infect Immun. 1993 May;61(5):2238-41. doi: 10.1128/iai.61.5.2238-2241.1993.
Abstract
Recently, we reported that murine antibody responses to the 23-valent pneumococcal polysaccharide (Pnu-Imune) vaccine declined with age. Here we present data to support the concept that age-associated immune defects are not only due to intrinsic defects in immune cells but are also due to extrinsic factors emanating from the neuroendocrine system. We found that supplementation with dehydroepiandrosterone, a steroid hormone known to be reduced in the aged, corrects the immune deficiency of aged mice and significantly enhanced their splenic immune responses to the Pnu-Imune vaccine.
摘要
最近，我们报道了小鼠对23价肺炎球菌多糖（Pnu-Imune）疫苗的抗体反应随年龄增长而下降。在此，我们提供数据以支持这样一种观点，即与年龄相关的免疫缺陷不仅归因于免疫细胞的内在缺陷，还归因于神经内分泌系统产生的外在因素。我们发现，补充脱氢表雄酮（一种已知在老年时会减少的类固醇激素）可纠正老年小鼠的免疫缺陷，并显著增强它们对Pnu-Imune疫苗的脾脏免疫反应。
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