成年志愿者对单独及联合接种的19F型和19A型肺炎球菌多糖的抗体反应。
Antibody responses in adult volunteers to pneumococcal polysaccharide types 19F and 19A administered singly and in combination.
作者信息
Penn R L, Lewin E B, Douglas R G, Schiffman G, Lee C J, Robbins J B
出版信息
Infect Immun. 1982 Jun;36(3):1261-2. doi: 10.1128/iai.36.3.1261-1262.1982.
Abstract
The immunogenicity of the two major group 19 pneumococcal polysaccharides, types 19F and 19A, was studied in human volunteers. Antibody responses after vaccination with either 50 micrograms of type 19F polysaccharide, 50 micrograms of type 19A polysaccharide, or 25 micrograms of both polysaccharides premixed in a single injection revealed that the combined vaccine was immunogenic for both types, but that the optimal immunogen for each was the homologous polysaccharide. We concluded that vaccination with type 19F polysaccharide antigen, included in the current pneumococcal vaccine, does not induce a satisfactory heteroimmunogenic response to type 19A.
摘要
在人类志愿者中研究了两种主要的19型肺炎球菌多糖（19F型和19A型）的免疫原性。分别接种50微克19F型多糖、50微克19A型多糖或单次注射预先混合的25微克两种多糖后，抗体反应表明联合疫苗对两种类型均具有免疫原性，但每种类型的最佳免疫原是同源多糖。我们得出结论，目前肺炎球菌疫苗中含有的19F型多糖抗原接种后，不会对19A型产生令人满意的异源免疫反应。
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