Natali P G, Nicotra M R, Bartolazzi A, Cavaliere R, Bigotti A
Regina Elena Cancer Institute, Rome, Italy.
Int J Cancer. 1993 Apr 22;54(1):68-72. doi: 10.1002/ijc.2910540112.
The cell-surface heterodimers of the integrin family of molecules, which mediate cell-cell and cell-substratum interactions, are likely to be functionally relevant in local and metastatic tumor growth. In the present study we have analyzed whether the alpha 3/beta 1 receptor for collagen, laminin and fibronectin undergoes changes in expression during tumor progression in cutaneous malignant melanoma (CMM). The results of this study have demonstrated that, while low levels of VLA3 expression are detectable in benign lesions, in primary melanomas the heterodimer undergoes progressive increase in expression which correlates with the degree of dermal invasiveness. Metastatic lesions were found VLA3 positive in 82% of cases. Furthermore, the heterodimer is homogeneously expressed in multiple autologous metastases. The presence of VLA3 correlates with detection of at least one of the ligands in 45% of the cases studied. These findings provide additional evidence that tumor progression in CMM is associated with changes in integrin phenotypes which include the alpha 3/beta 1 heterodimer.
整合素家族分子的细胞表面异二聚体介导细胞间和细胞与基质间的相互作用，可能在局部和转移性肿瘤生长中发挥功能作用。在本研究中，我们分析了胶原蛋白、层粘连蛋白和纤连蛋白的α3/β1受体在皮肤恶性黑色素瘤（CMM）肿瘤进展过程中表达是否发生变化。本研究结果表明，虽然在良性病变中可检测到低水平的VLA3表达，但在原发性黑色素瘤中，该异二聚体的表达逐渐增加，且与真皮浸润程度相关。在82%的病例中，转移性病变的VLA3呈阳性。此外，该异二聚体在多个自体转移灶中呈均匀表达。在所研究的45%的病例中，VLA3的存在与至少一种配体的检测相关。这些发现提供了额外的证据，表明CMM中的肿瘤进展与整合素表型的变化有关，其中包括α3/β1异二聚体。
