Kato T, Kamei A, Takashima S, Ozaki T
Division of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Tokyo, Japan.
J Cereb Blood Flow Metab. 1993 May;13(3):516-20. doi: 10.1038/jcbfm.1993.66.
Near-infrared spectroscopy (NIRS) was used to monitor human visual cortical function during and after photic stimulation (PS) in five adult volunteers. Cerebral blood volume (CBV) increased on the occipital surface during PS, but NIRS parameters did not change on the frontal surface. The increase in CBV was caused by a rapid increase in oxyhemoglobin with but a small increase in deoxyhemoglobin, suggesting cerebral vascular dilatation with decreased oxygen consumption. After PS stopped, CBV promptly decreased and then slightly increased again. Cytochrome aa3 did not show any change during and after PS. These phenomena reappeared following repeated PS in all five subjects. These results may represent the first step in the development of NIRS imaging.
在五名成年志愿者中，使用近红外光谱（NIRS）监测光刺激（PS）期间及之后的人类视觉皮质功能。光刺激期间枕叶表面的脑血容量（CBV）增加，但近红外光谱参数在额叶表面没有变化。CBV的增加是由于氧合血红蛋白快速增加，而脱氧血红蛋白仅有少量增加，提示脑血管扩张且氧消耗减少。光刺激停止后，CBV迅速下降，然后再次略有增加。细胞色素aa3在光刺激期间及之后未显示任何变化。在所有五名受试者中重复光刺激后，这些现象再次出现。这些结果可能代表了近红外光谱成像发展的第一步。
