Tsuchida E, Nishide H, Hasegawa E, Chika Y, Fukuzumi M, Komatsu T
Department of Polymer Chemistry, Waseda University, Tokyo, Japan.
J Inorg Biochem. 1993 Mar;49(4):255-64. doi: 10.1016/0162-0134(93)80061-d.
Synthesis and characterization of two amphiphilic tetraphenylporphinatoiron complexes having a glycerophosphocholine or an alkyl phosphoserine group are described. These porphinatoiron(II) complexes with 1-dodecyl-2-methyl-imidazole (L2MIm) were efficiently embedded in the bilayer of a phospholipid vesicle due to their high compatibility with lipids, similar to the heme substituted with four alkyl amphiphilic chains (lipid-heme). Oxygen transporting ability of the phospholipid vesicles embedded with hemes were similar to that of hemoglobin (Hb) in red blood cells.
描述了两种具有甘油磷酸胆碱或烷基磷酸丝氨酸基团的两亲性四苯基卟啉铁配合物的合成与表征。这些卟啉铁（II）与1-十二烷基-2-甲基咪唑（L2MIm）的配合物由于与脂质具有高度相容性，能有效地嵌入磷脂囊泡的双层中，类似于被四个烷基两亲链取代的血红素（脂质-血红素）。嵌入血红素的磷脂囊泡的氧气运输能力与红细胞中的血红蛋白（Hb）相似。
