Loprinzi C L, Duffy J, Ingle J N
Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905.
J Clin Oncol. 1993 Apr;11(4):768-70. doi: 10.1200/JCO.1993.11.4.768.
This report describes a previously unreported clinical phenomenon that occurs in some patients after completion of combination chemotherapy.
Eight case reports are presented. Affected patients developed a syndrome of myalgias/arthralgias within several months of completing cyclophosphamide/fluorouracil (5FU)-containing adjuvant combination chemotherapy for breast cancer. These symptoms did not appear to be related to cancer recurrence or any common rheumatologic disorder. The syndrome generally resolved over several months.
Postchemotherapy rheumatism is a syndrome of myalgias/arthralgias that usually develops 1 to 3 months after completion of adjuvant chemotherapy. Recognition of this syndrome can limit the need for extensive work-ups to exclude recurrent breast cancer or inflammatory rheumatologic diseases.
本报告描述了一种在联合化疗完成后部分患者中出现的此前未报道的临床现象。
呈现了8例病例报告。受影响的患者在完成含环磷酰胺/氟尿嘧啶（5FU）的乳腺癌辅助联合化疗后的数月内出现了肌痛/关节痛综合征。这些症状似乎与癌症复发或任何常见的风湿性疾病无关。该综合征通常在数月内缓解。
化疗后风湿病是一种肌痛/关节痛综合征，通常在辅助化疗完成后1至3个月出现。认识到这种综合征可以减少为排除复发性乳腺癌或炎性风湿性疾病而进行广泛检查的必要性。
