Page D A, Carlson G P
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907-1334.
J Toxicol Environ Health. 1993 Apr;38(4):369-79. doi: 10.1080/15287399309531725.
Pyridine has been shown to be an effective inducer of the ethanol-inducible cytochrome P-450IIE1 in both liver and lung. The oxidation of 2-butanol by rat liver is inducible by chronic ethanol consumption. The purpose of this study was to determine the effect of pyridine on the hepatic and pulmonary metabolism of butanol. Comparisons were made between rat and rabbit. Acute pyridine treatment (200 mg/kg, ip) increased hepatic metabolism of 2-butanol in the rat twofold and in the rabbit threefold. The effect of pyridine on hepatic butanol oxidase is similar to the effect reported by other investigators for ethanol administered in the drinking water for 3 wk. Control rabbit pulmonary butanol oxidase activity was 10-fold higher than that in the rat. Pyridine decreased pulmonary butanol oxidase activity in the rabbit. The effect was demonstrated both in vitro and in the isolated perfused rabbit lung. Pyridine had no effect on pulmonary butanol oxidase activity in the rat.
吡啶已被证明是肝脏和肺中乙醇诱导型细胞色素P - 450IIE1的有效诱导剂。大鼠肝脏对2 - 丁醇的氧化可被长期摄入乙醇诱导。本研究的目的是确定吡啶对丁醇肝脏和肺代谢的影响。对大鼠和兔子进行了比较。急性吡啶处理（200毫克/千克，腹腔注射）使大鼠肝脏中2 - 丁醇的代谢增加了两倍，兔子增加了三倍。吡啶对肝脏丁醇氧化酶的作用类似于其他研究者报道的给大鼠饮用3周乙醇的作用。对照兔子肺丁醇氧化酶活性比大鼠高10倍。吡啶降低了兔子肺丁醇氧化酶活性。这种作用在体外和离体灌注的兔肺中均得到证实。吡啶对大鼠肺丁醇氧化酶活性没有影响。
