• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

果蝇肿瘤致死性造血致癌基因是霍普斯科奇基因座中的一个显性突变。

The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus.

作者信息

Hanratty W P, Dearolf C R

机构信息

Department of Biological Sciences, University of Southern Mississippi, Hattiesburg 39406.

出版信息

Mol Gen Genet. 1993 Apr;238(1-2):33-7. doi: 10.1007/BF00279527.

DOI:10.1007/BF00279527
PMID:8479437
Abstract

The Drosophila Tumorous-lethal (Tum-l) mutation acts as an activated oncogene, causing hematopoietic neoplasms, overproliferation, and premature differentiation. Tum-l is a dominant mutation in the hopscotch (hop) locus, which is required for cell division and for proper embryonic segmentation. The Tum-l temperature-sensitive period for melanotic tumor formation includes most of larval and pupal development.

摘要

果蝇的肿瘤致死（Tum-l）突变作为一种激活的癌基因，会导致造血肿瘤、过度增殖和过早分化。Tum-l是霍普斯科奇（hop）基因座中的一个显性突变，该基因座是细胞分裂和正常胚胎分割所必需的。Tum-l导致黑色素瘤形成的温度敏感期包括幼虫和蛹发育的大部分阶段。

相似文献

1
The Drosophila Tumorous-lethal hematopoietic oncogene is a dominant mutation in the hopscotch locus.果蝇肿瘤致死性造血致癌基因是霍普斯科奇基因座中的一个显性突变。
Mol Gen Genet. 1993 Apr;238(1-2):33-7. doi: 10.1007/BF00279527.
2
l(1)hopscotch, A larval-pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila.l(1)跳房子，一种幼虫-蛹期合子致死基因，对果蝇的体节形成具有特定的母体效应。
Dev Biol. 1986 Nov;118(1):28-41. doi: 10.1016/0012-1606(86)90070-9.
3
A Genetic Screen Reveals an Unexpected Role for Yorkie Signaling in JAK/STAT-Dependent Hematopoietic Malignancies in .一项基因筛选揭示了Yorkie信号通路在果蝇JAK/STAT依赖性造血系统恶性肿瘤中的意外作用。
G3 (Bethesda). 2017 Aug 7;7(8):2427-2438. doi: 10.1534/g3.117.044172.
4
Drosophila awdK-pn, a homologue of the metastasis suppressor gene nm23, suppresses the Tum-1 haematopoietic oncogene.果蝇awdK-pn是转移抑制基因nm23的同源物，可抑制Tum-1造血癌基因。
Nat Genet. 1993 Jun;4(2):195-201. doi: 10.1038/ng0693-195.
5
The genetics of the Dras3-Roughened-ecdysoneless chromosomal region (62B3-4 to 62D3-4) in Drosophila melanogaster: analysis of recessive lethal mutations.黑腹果蝇中Dras3 - 粗糙 - 无蜕皮激素染色体区域（62B3 - 4至62D3 - 4）的遗传学：隐性致死突变分析
Genetics. 1989 Oct;123(2):327-36. doi: 10.1093/genetics/123.2.327.
6
Analysis of larval segmentation in lethal genotypes associated with the antennapedia gene complex in Drosophila melanogaster.黑腹果蝇中与触角足基因复合体相关的致死基因型幼虫体节分析。
Dev Biol. 1981 Jan 15;81(1):51-64. doi: 10.1016/0012-1606(81)90347-x.
7
Development and complementation of lethal mutations at the dumpy locus of Drosophila melanogaster.黑腹果蝇短粗基因座致死突变的发育与互补作用
Genet Res. 1971 Jun;17(3):173-83. doi: 10.1017/s0016672300012209.
8
Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.果蝇Janus激酶（JAK）的激活会导致造血系统肿瘤和发育缺陷。
EMBO J. 1995 Jun 15;14(12):2857-65. doi: 10.1002/j.1460-2075.1995.tb07285.x.
9
Temperature-sensitive mutations in Drosophila melanogaster. 8. Temperature-sensitive periods of the lethal and morphological phenotypes of selected combinations of notch-locus mutations.黑腹果蝇中的温度敏感突变。8. 缺口基因座突变特定组合的致死和形态学表型的温度敏感期。
Dev Biol. 1973 Jun;32(2):282-96. doi: 10.1016/0012-1606(73)90241-8.
10
The Friend of GATA protein U-shaped functions as a hematopoietic tumor suppressor in Drosophila.GATA蛋白的Friend U形在果蝇中作为造血肿瘤抑制因子发挥作用。
Dev Biol. 2007 Nov 15;311(2):311-23. doi: 10.1016/j.ydbio.2007.08.011. Epub 2007 Aug 16.

引用本文的文献

1
Venom vesicles from the parasitoid facilitate venom protein entry into host immune cells.来自寄生蜂的毒液囊泡有助于毒液蛋白进入宿主免疫细胞。
bioRxiv. 2025 May 14:2025.05.08.652939. doi: 10.1101/2025.05.08.652939.
2
Malignant JAK-signaling: at the interface of inflammation and malignant transformation.恶性JAK信号传导：炎症与恶性转化的交汇点
Leukemia. 2025 May;39(5):1011-1030. doi: 10.1038/s41375-025-02569-8. Epub 2025 Mar 26.
3
The matrix glycoprotein Papilin maintains the haematopoietic progenitor pool in Drosophila lymph glands.

本文引用的文献

1
The distribution of randomly recovered X-ray-induced sex-linked genetic effects in Drosophila melanogaster.黑腹果蝇中随机恢复的X射线诱导的性连锁遗传效应的分布。
Genetics. 1981 Nov-Dec;99(3-4):461-80. doi: 10.1093/genetics/99.3-4.461.
2
Fine cytogenetical analysis of the band 10A1-2 and the adjoining regions in the Drosophila melanogaster X chromosome. I. Cytology of the region and mapping of chromosome rearrangement.黑腹果蝇X染色体10A1 - 2带及相邻区域的精细细胞遗传学分析。I. 该区域的细胞学及染色体重排图谱
Chromosoma. 1981;82(1):9-23. doi: 10.1007/BF00285746.
3
Fine cytogenetical analysis of the band 10A1-2 and the adjoining regions in the Drosophila melanogaster X chromosome. II. Genetical analysis.
基质糖蛋白Papilin维持果蝇淋巴腺中的造血祖细胞池。
Development. 2025 Apr 1;152(7). doi: 10.1242/dev.204367. Epub 2025 Apr 10.
4
Host JAK-STAT activity is a target of parasitoid wasp virulence strategies.宿主 JAK-STAT 活性是寄生蜂毒力策略的靶标。
PLoS Pathog. 2024 Jul 1;20(7):e1012349. doi: 10.1371/journal.ppat.1012349. eCollection 2024 Jul.
5
parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids.寄生蜂进入太空：太空飞行对宿主及其寄生蜂的意外影响。
iScience. 2023 Dec 16;27(1):108759. doi: 10.1016/j.isci.2023.108759. eCollection 2024 Jan 19.
6
A feedforward loop between JAK/STAT downstream target p115 and STAT in germline stem cells.生殖干细胞中 JAK/STAT 下游靶蛋白 p115 与 STAT 之间的正反馈回路。
Stem Cell Reports. 2023 Oct 10;18(10):1940-1953. doi: 10.1016/j.stemcr.2023.08.007. Epub 2023 Sep 7.
7
The JAK-STAT pathway at 30: Much learned, much more to do.JAK-STAT 通路 30 年：学无止境，任重道远。
Cell. 2022 Oct 13;185(21):3857-3876. doi: 10.1016/j.cell.2022.09.023.
8
Germline sex determination regulates sex-specific signaling between germline stem cells and their niche.种系性别决定调节种系干细胞与其微环境之间的性别特异性信号传导。
Cell Rep. 2022 Apr 5;39(1):110620. doi: 10.1016/j.celrep.2022.110620.
9
Maheshvara regulates JAK/STAT signaling by interacting and stabilizing hopscotch transcripts which leads to apoptosis in Drosophila melanogaster.马希什瓦拉通过与霍普斯考特转录本相互作用和稳定，调节 JAK/STAT 信号通路，从而导致果蝇细胞凋亡。
Cell Death Dis. 2021 Apr 6;12(4):363. doi: 10.1038/s41419-021-03649-0.
10
Janus Kinases in Leukemia.白血病中的Janus激酶
Cancers (Basel). 2021 Feb 14;13(4):800. doi: 10.3390/cancers13040800.
黑腹果蝇X染色体10A1-2带及相邻区域的精细细胞遗传学分析。II. 遗传学分析。
Chromosoma. 1981;82(1):25-40. doi: 10.1007/BF00285747.
4
A genetic melanotic neoplasm of Drosophila melanogaster.果蝇的一种遗传性黑素瘤性肿瘤。
Dev Biol. 1981 Apr 30;83(2):238-49. doi: 10.1016/0012-1606(81)90470-x.
5
Alterations in the production of hemocytes due to a neoplastic mutation of Drosophila melanogaster.
J Invertebr Pathol. 1984 Nov;44(3):324-8. doi: 10.1016/0022-2011(84)90030-2.
6
Cell surface changes associated with cellular immune reactions in Drosophila.
Science. 1984 Sep 14;225(4667):1166-8. doi: 10.1126/science.6433482.
7
Salivary chromosome bands and the frequency of crossing over in Drosophila melanogaster.黑腹果蝇的唾液腺染色体带与交换频率
Genetics. 1971 Apr;67(4):497-513. doi: 10.1093/genetics/67.4.497.
8
The recovery and preliminary characterization of X chromosome mutants affecting imaginal discs of Drosophila melanogaster.影响黑腹果蝇成虫盘的X染色体突变体的恢复与初步表征。
Dev Biol. 1972 Jan;27(1):71-83. doi: 10.1016/0012-1606(72)90113-3.
9
l(1)hopscotch, A larval-pupal zygotic lethal with a specific maternal effect on segmentation in Drosophila.l(1)跳房子，一种幼虫-蛹期合子致死基因，对果蝇的体节形成具有特定的母体效应。
Dev Biol. 1986 Nov;118(1):28-41. doi: 10.1016/0012-1606(86)90070-9.
10
The question of the total gene number in Drosophila melanogaster.黑腹果蝇基因总数的问题。
Genetics. 1986 Aug;113(4):869-95. doi: 10.1093/genetics/113.4.869.