2,4-二取代噻唑氨基酮衍生物的抗炎活性
Antiinflammatory activity of aminoketone derivatives of 2,4-disubstituted thiazoles.
作者信息
Hadjipavlou Litina D, Geronikaki A, Sotiropoulou E
机构信息
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Thessaloniki, Greece.
出版信息
Res Commun Chem Pathol Pharmacol. 1993 Mar;79(3):355-62.
PMID:8480080
Abstract
A group of nine aminoketones, 2,4-disubstituted thiazole derivatives were tested in vivo in order to evaluate their biological activity. Antiinflammatory activity was studied by means of the carrageenin-induced mouse paw edema. Writhing induced by acetic acid in rats used to evaluate the analgesic activity. The results are discussed from the view of structure activity relationship.
摘要
为了评估其生物活性，对一组9种氨基酮、2,4-二取代噻唑衍生物进行了体内试验。通过角叉菜胶诱导的小鼠爪肿胀来研究其抗炎活性。用乙酸诱导大鼠扭体来评估镇痛活性。从构效关系的角度对结果进行了讨论。
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