土耳其人群中HLA I类和II类抗原与风湿热的关联。

Association of HLA class I and class II antigens with rheumatic fever in a Turkish population.

作者信息

Olmez U, Turgay M, Ozenirler S, Tutkak H, Düzgün N, Duman M, Tokgöz G

机构信息

Department of Immunology, Medical School of Ankara University, Turkey.

出版信息

Scand J Rheumatol. 1993;22(2):49-52. doi: 10.3109/03009749309095114.

DOI:10.3109/03009749309095114

PMID:8480138

Abstract

The distribution of class I and class II HLA antigens of 100 Turkish patients with rheumatic fever, 77 of whom had cardiac involvement, was examined. We compared the results with a control group of identical origin. The frequency of HLA A10 and HLA B35 antigens were found significantly higher in patients with rheumatic fever (p < 0.05, p < 0.01, respectively). The frequency of HLA A10 and HLA DRw11 in patients with cardiac involvement were significantly higher than in those without cardiac involvement (p < 0.05, p < 0.01, respectively). On the other hand, HLA Cw2 antigen frequency was found significantly higher in patients without cardiac involvement than in those with rheumatic heart disease (p < 0.05). We support the concept that rheumatic fever is an immunological reaction to group A, beta hemolytic streptococci in individuals who have genetic predisposition.

摘要

对100名土耳其风湿热患者的I类和II类HLA抗原分布进行了检查，其中77人有心脏受累情况。我们将结果与相同来源的对照组进行了比较。发现风湿热患者中HLA A10和HLA B35抗原的频率显著更高（分别为p < 0.05，p < 0.01）。有心脏受累的患者中HLA A10和HLA DRw11的频率显著高于无心脏受累的患者（分别为p < 0.05，p < 0.01）。另一方面，无心脏受累的患者中HLA Cw2抗原频率显著高于风湿性心脏病患者（p < 0.05）。我们支持这样的观点，即风湿热是具有遗传易感性的个体对A组β溶血性链球菌的免疫反应。