Falkenbach A, Wigand R, Unkelbach U, Jörgens K, Martinovic A, Scheuermann E H, Seiffert U B, Kaltwasser J P
Department of Medicine, Johann Wolfgang Goethe-University Hospital, Frankfurt am Main, Germany.
Scand J Rheumatol. 1993;22(2):83-5. doi: 10.3109/03009749309095120.
The serum activity of beta-glucuronidase (beta-gluc) has been presumed to indicate the disease activity in rheumatoid arthritis (RA). In 10 patients with RA the serum beta-gluc was repeatedly determined after the initiation of a treatment with cyclosporin for one year. A significant increase of beta-gluc was found after 8, 12 and 16 weeks compared to the values before treatment, while the concentration of the soluble interleukin 2-receptor decreased. The data reveal, that beta-gluc is not a useful indicator of the disease activity during cyclosporin treatment.
β-葡萄糖醛酸酶（β-gluc）的血清活性被推测可指示类风湿性关节炎（RA）的疾病活动情况。在10例类风湿性关节炎患者中，在开始使用环孢素治疗一年后，反复测定血清β-gluc。与治疗前的值相比，在第8、12和16周时发现β-gluc显著升高，而可溶性白细胞介素2受体的浓度降低。数据显示，在环孢素治疗期间，β-gluc不是疾病活动的有用指标。
