Asakura H, Shiratori Y, Jokaji H, Saito M, Uotani C, Kumabashiri I, Morishita E, Yamazaki M, Matsuda T
Department of Internal Medicine (III), Kanazawa University School of Medicine, Japan.
Acta Haematol. 1993;89(1):22-5. doi: 10.1159/000204477.
Plasma levels of prothrombin fragment F 1 + 2 (PTF) and thrombin-antithrombin III complex (TAT) were assayed in 86 cases of disseminated intravascular coagulation (DIC). A significant elevation of both parameters was observed in most cases of DIC, which suggested that the in vivo generation of thrombin is highly accelerated by the cleavage of the prothrombin molecule by factor Xa. On the contrary, no significant elevation of plasma levels of PTF was observed in cases of DIC with severe hepatic failure or fulminant hepatitis in spite of significant elevation of TAT. Plasma levels of PTF were directly proportional to those of TAT in 86 cases of DIC as a whole (r = 0.682, p < 0.001). The measurement of both parameters was considered to be useful to estimate the hemostatic activation in DIC.
检测了86例弥散性血管内凝血（DIC）患者的血浆凝血酶原片段F1 + 2（PTF）和凝血酶 - 抗凝血酶III复合物（TAT）水平。在大多数DIC病例中观察到这两个参数均显著升高，这表明凝血酶原分子被因子Xa裂解后，体内凝血酶的生成高度加速。相反，在伴有严重肝功能衰竭或暴发性肝炎的DIC病例中，尽管TAT显著升高，但未观察到PTF血浆水平的显著升高。总体而言，86例DIC患者的PTF血浆水平与TAT血浆水平成正比（r = 0.682，p < 0.001）。认为同时检测这两个参数有助于评估DIC中的止血激活情况。
